Designer modulators

Nonsteroidal selective androgen receptors modulators (SARMs): designer androgens with flexible structures provide clinical promise.

Androgens play an essential role in differentiation and growth of the male reproductive tract, pubertal maturation and development of secondary male sex characteristics, initiation and regulation of spermatogenesis, and male sexual behavior (1). Steroidal androgens increase muscle mass, bone mass, and strength; stimulate male pattern baldness; and alter serum lipid profiles and fat distribution...

Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling.

Novel psychoactive substances are newly used designer drugs ("internet drugs", "research chemicals", "legal highs") potentially posing similar health risks to classic illicit substances. Chemically, many novel psychoactive substances can be classified as phenethylamines, amphetamines, synthetic cathinones, piperazines, pipradrols/piperidines, aminoindanes benzofurans, and tryptamines. Pharmacol...

‘Designer’ babies

The remaining hurdle to the creation of babies specifically to save the life of an ailing brother or sister was removed in Britain last month by the fertility regulatory body to the delight of afflicted families and alarm of those who fear the advent of a 'designer' baby age. The decision of the UK's Human Fertilisation and Embryology Authority gives new hope to the parents of a two-year-old bo...

Designer Manual

Designer Children: